To assess the oxidative assaults and antioxidant defense, oxidative stress markers, including lipid peroxidation level, protein carbonylation level, Upholstered Arm Chair GSSG/GSH ratio and nonenzymatic antioxidants such as total glutathione, ascorbic acid and uric acid, in liver and brain tissues of hibernating common Asian toads, Duttaphrynus mel
Contemporary European Welfare State Transformations and the Risk of Erosion of Social Rights: A Normative Analysis of the Social Investment Approach
Over the last decades, there has been a huge debate on the transformations of the European Welfare State.The issue of its financial sustainability together with the emergence of new social risks has put under pressure the traditional model of social protection and created the conditions for a change in the gist of the welfare state provisions.In th
Computer-aided design and synthesis of 3-carbonyl-5-phenyl-1H-pyrazole as highly selective and potent BRAFV600E and CRAF inhibitor
BRAF belongs to the upstream portion of the 20Amp Mains Plug Top MAPK pathway, which is involved in cell proliferation and survival.When mutations occur in BRAF, downstream MEK and ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer.Over the years, small molecules targeting BRAFV600E have been discovered to be very effecti